Neuroblastoma, a form of cancer that occurs in infants and children, is rarely found in children older than 10 years. The cells of this cancer usually resemble very primitive developing nerve cells found in an embryo or fetus. (The term neuro indicates "nerves," while blastoma refers to a cancer that affects immature or developing cells).

Neurons (nerve cells) are the main component of the brain and spinal cord and of the nerves that connect them to the rest of the body. These cells are essential for thinking, sensation, and movement. There is a part of the nervous system that we are rarely aware of, called the autonomic nervous system, which controls involuntary body functions such as heart rate, blood pressure, and digestion. The sympathetic nervous system is a part of the autonomic nervous system. It includes:
  • nerve fibers that run alongside the spinal cord
  • clusters of nerve cells called ganglia (plural of ganglion) at certain points along the path of the nerve fibers
  • nerve-like cells found in the medulla (center) of the adrenal glands. The adrenals are triangular-shaped glands located above the kidneys. The hormone adrenaline comes from these cells in the adrenal gland.

About one-third of neuroblastomas start in the adrenal glands, another third begin in the sympathetic nervous system ganglia of the abdomen, and the rest start in sympathetic ganglia of the chest or neck or the parasympathetic ganglia (another part of the autonomic nervous system) in the pelvis. Some can start in the spinal cord. Rarely, a neuroblastoma may have spread so extensively by the time it is found that doctors are unable to determine exactly where it started.

Not all childhood autonomic nervous system tumors are malignant (cancerous). There is a benign tumor called ganglioneuroma, which is composed of mature ganglion and nerve sheaths that do not continue to grow.


Revised 10-28-03

For more information about Neuroblastoma you can go to:
http://www.cancer.org







 















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